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. 2022 Jan 24;8:36. doi: 10.1038/s41420-022-00818-8

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A H522 and H460 cells were exposed to vehicle or TERB (25 μM). IC50 of apatinib was measured with CCK8 assay. B Pictures of colony formation in H522 and H460 cells treated with vehicle, TERB, apatinib, or both modalities. C The clone numbers in four groups. D Representative images of EdU (EdU labeled with red, nuclei with blue). E The percentages of positive cells in four groups. (**P < 0.01, ***P < 0.001, NS not significant, compared with apatinib).