Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 24;8:36. doi: 10.1038/s41420-022-00818-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — A H522 and H460 cells were treated with or without apatinib (20 μM) and propranolol (50 μM) for 48 h. The relative protein level of CREB, p-CREB, PSAT1 was detected through Western blot. B A positive correlation between CREB and PSAT1 expression in lung cancer according to TCGA database. C qRT-PCR analysis of PSAT1 mRNA levels in H522 and H460 cells after KG-501 treatment. D Western blot analysis of CREB, p-CREB, PSAT1 expression in H522 and H460 cells after ADRB2 knockdown. E H522 and H460 cells were transfected with indicated siRNAs for 48 h, and the samples were exposed to different concentrations of apatinib. IC50 of apatinib was measured with CCK8 assay. F H460 cells were treated with/without apatinib (20 μM) and KG-501 (25 μM) for 48 h. The apoptosis index was detected by flow cytometry. G The percentage of apoptotic cells in H522 and H460 cells. H Representative co-localization images stained with ADRB2 (green) and VEGFR2 (red) in H522 and H460 cells. I Anti-ADRB2 antibodies immunoprecipitated endogenous ADRB2 and Co-IP VEGFR2 by Western blot analysis. (**P < 0.01, compared with vehicle).