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. 2022 Jan 24;12:1248. doi: 10.1038/s41598-022-05193-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Selumetinib combined with KRT-232 inhibits tumor growth in CRC PDX models. Female athymic nu/nu mice bearing C1035 PDXs were treated with vehicle, selumetinib 15 mg/kg, KRT-232 15 mg/kg or the combination of both. The other four PDX were treated with vehicle, selumetinib 25 mg/kg, KRT-232 15 mg/kg or the combination of both. Selumetinib and KRT-232 were both administered daily. The treatment was stopped at 28 days or when tumor diameter reached 1.5 cm. Left panel, individual tumor volume change (mm³). Middle panel, growth curve graphs demonstrating mean change in tumor volume percentage ± SEM. Right panel, event-free survival curves. The C1185 model did not have any events and is not shown here.