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. 2022 Jan 24;12:1235. doi: 10.1038/s41598-022-05360-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Burn injury induces M-CSF secretion in humans and mice. (A) Sample legend and plot showing M-CSF levels in burn patient plasma samples, n = 32. Shaded area represents the M-CSF ELISA kit manufacturer’s reported range (134–434 pg/ml) for healthy human plasma and the dashed line represents M-CSF levels measured in a pooled plasma sample from healthy humans. (B) Serum M-CSF levels in sham or burn injured mice on post burn day (PBD) 1, 3, and 7, n = 10 sham and n = 8 burn/day. Data shown as box plots with whiskers at min and max. *p < 0.05, ANOVA each post burn day versus sham.