Table 1.

Effect of M-CSF neutralization on blood cells.

Parameter, units	Sham + isotype (n = 6)	Burn + isotype (n = 6)	Burn + anti-M-CSF (n = 6)
Neutrophils, K/µl	0.15 ± 0.03	0.68 ± 0.41*	1.23 ± 0.44#
Monocytes, K/µl	0.03 ± 0.03	0.05 ± 0.03	0.03 ± 0.01
Lymphocytes, K/µl	1.03 ± 0.29	1.06 ± 0.54	1.21 ± 0.50
Platelets, K/µl	826 ± 181	1194 ± 116*	1307 ± 120
Red cells, M/µl	8.64 ± 0.30	8.18 ± 0.21*	8.58 ± 0.32#
Hemoglobin, g/dL	14.10 ± 0.44	12.93 ± 0.12*	13.30 ± 0.42
Hematocrit, %	45.07 ± 1.30	42.22 ± 1.28*	42.95 ± 1.83
MCV, fL	52.17 ± 0.76	51.65 ± 1.24	50.08 ± 0.47#
Reticulocytes, K/µl	281 ± 22	318 ± 33	334 ± 65
IRF-M + H, %	58.0 ± 2.4	69.5 ± 2.8*	66.2 ± 3.7
Low CH retic, %	28.2 ± 3.2	31.5 ± 10.3	46.7 ± 5.7#
Hypo retic, %	9.9 ± 4.7	21.8 ± 9.6*	28.4 ± 3.8

Parameters determined on an automated hematology system are presented as mean ± SD.

Significance, ANOVA p < 0.05 is indicated by * for burn isotype versus sham isotype and ^#for burn anti-M-CSF versus burn isotype.