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. 2022 Jan 24;8:33. doi: 10.1038/s41420-022-00823-x

Fig. 7. p38 MAPK pathway mediates NOX4 to promote apoptosis and OS of SH-SY5Y cells.

Fig. 7

A MEM analysis of NOX4 and p38 MAPK significant co-expression. B The levels of NOX4, p–p38, and p38 in SH-SY5Y cells after different treatments measured by Western blot assay. C Cell proliferation in SH-SY5Y cells after different treatments. D Cell apoptosis in SH-SY5Y cells after different treatments. E SOD level in SH-SY5Y cells after different treatments. F MDA level in SH-SY5Y cells after different treatments. G ROS levels in SH-SY5Y cells after different treatments detected using DCFH-DA fluorescent staining. *p < 0.05 vs. SH-SY5Y cells without treatment, #p < 0.05 vs. oe-NC + DMSO; $p < 0.05 vs. oe-NOX4 + DMSO. Cell experiments were repeated three times independently.