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. 2022 Jan 24;12:1207. doi: 10.1038/s41598-022-05228-5

Figure 1.

Figure 1

High-fat diet-fed mice develop fatty liver and steatohepatitis. (A) body changes over time. Animals were fed a normal chow diet and tap water (NC NW) or high fructose/glucose, high fat Western Diet (WD SW) for up to 28 weeks. (B) High fat Western Diet was associated with a significant increase in terminal liver weight compared to CD NW-fed animals at 8, 20 and 28 weeks. (C) Disease severity expressed in percentage. (D) Gross liver from DIAMOND mice fed a control diet (NC NW) or high fat Western Diet (WD SW) for 8, 20 and 28 weeks. Representative liver sections stained with hematoxylin–eosin (H&E) of livers from CD NW or WD SW mice at 8, 20 or 28 weeks of diet are shown. Original magnification, × 20. (E) Histology score for steatosis, hepatocyte ballooning, lobular inflammation, fibrosis and NAFLD Activity Score were quantified. Data are expressed as the mean ± SEM for 4–10 mice per group. For body weight NC NW AUC = 683.1 ± 20.2; WD SW AUC = 1131 ± 50.2. WD SW AUC < 0.001 vs NC NW AUC.