Figure 6.

¹H-MRS of the mouse thalamus. (A) Representative axial and sagittal T2_turboRARE weighted images with fat suppression of mouse brain and corresponding voxel location centered in the thalamic region (2 × 2 × 2 mm³). (B) Representative in vivo pre-fitting and post-fitting ¹H-MRS spectra from NC NW mouse thalamus at baseline (T0) and after 28 weeks (T4) (left) and WD SW mouse thalamus at baseline (T0) and after 28 weeks (T4) (right), performed by Tarquin. In post-fitting ¹H-MRS spectra the black trace represents the processed signal, the red trace is the model signal, while the green trace is the baseline plus the individual metabolite spectral lines.