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. 2022 Jan 11;12:811584. doi: 10.3389/fphar.2021.811584

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Copyright © 2022 Yang, Zhou, Xu, Ge, Wang, Zhang, Miao and Deng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of aprepitant on carrageenan-induced mechanical allodynia and microglial activation in the spinal cord. (A) Withdrawal threshold in treatment groups versus control mice. Eleven to twelve mice were included in each of the groups. Data are expressed as mean ± SEM. One-way ANOVA, **p < 0.01 versus control, ##p < 0.01 versus carrageenan. (B) The representative immunoblots and graphic representation of relative protein and phosphorylation of ERK, JNK and p38 MAPK in spinal cord. (C) The mRNA expression of MCP-1, IL-1β, TNF-α and IL-6 in spinal cord of mice with carrageenan-induced inflammatory pain (n = 4). Data are expressed as mean ± SEM. Two-way ANOVA, *p < 0.05, **p < 0.01 versus control, #p < 0.05, ##p < 0.01 versus carrageenan.