Table 3.
Association results of three SNV-haplotypes with hospitalization status (inpatient and outpatient) in a case–control study of 683 COVID-19 patients: frequencies of haplotypes among outpatients and inaptients, estimated coefficients, and Fisher's exact p-values, respectively, across three haplotypes.
| Hap | Discovery Set | Replication Set | |||||
|---|---|---|---|---|---|---|---|
| OUT | IN | p-value | OUT | IN | p-value | WA (%) | |
| H1:t19839-g28881-g28882-g28883 | |||||||
| caac | 43 (11.08) | 2.84E−11 | 35 (7.35) | 110 (22.54) | 2.21E−10 | 16.83 | |
| taac | 8 (2.71) | 11 (2.84) | 45 (9.45) | 41 (8.4) | 5.93 | ||
| tagg | 2 (0.42) | 1 (0.2) | 0.06 | ||||
| tggg | 287 (97.29) | 334 (86.08) | 394 (82.77) | 336 (68.85) | 75.84 | ||
| H2:a20268-c28854 | |||||||
| ac | 294 (99.66) | 341 (87.89) | 4.56E−11 | 361 (75.84) | 399 (81.76) | 5.28E−02 | 87.95 |
| at | 2 (0.52) | 7 (1.47) | 2 (0.41) | 0.60 | |||
| gc | 1 (0.34) | 4 (1.03) | 2 (0.42) | 1 (0.2) | 0.55 | ||
| gt | 40 (10.31) | 106 (22.27) | 86 (17.62) | 8.55 | |||
| nc* | 1 (0.26) | 1.33 | |||||
| H3:c1059-g25563 | |||||||
| cg | 94 (31.86) | 199 (51.29) | 2.40E−06 | 195 (40.97) | 239 (48.98) | 7.19E−02 | 54.95 |
| ct | 8 (2.71) | 8 (2.06) | 15 (3.15) | 15 (3.07) | 2.70 | ||
| tg | 4 (1.36) | 3 (0.77) | 2 (0.42) | 3 (0.61) | 0.04 | ||
| tt | 189 (64.07) | 176 (45.36) | 264 (55.46) | 231 (47.34) | 41.04 | ||
| yg* | 2 (0.52) | 0.00 | |||||
Also included are haplotype frequencies in general population of Washington state (far right column).
*n—untyped nucleotide, y—ambiguity typing of either c or t.