TABLE 2.

Regulatory role of the circRNA-miRNA-TFs axis in various aspects of carcinogenesis.

S.No.	CircRNA	Cancer type	miRNA	Target mRNA	Outcome	References
1	CircPTK2	NSCLC	miR-429/miR-200b-3p	TIF1 γ TGF-ß/SMAD	Inhibits cancer proliferation and EMT	Wang et al. (2018b)
2	CircHIPK3	Colorectal	miR-7	YY1	Promotes cancer progression	Zeng et al. (2018)
				EGFR	Inhibits cancer cell apoptosis
				FAK
3	CircANKS1B	Breast	miR-148a-3p/miR-152-3p	USF1	Promotes invasion, metastasis, and EMT	Zeng et al. (2018)
				TGF-ß
				SMAD
4	CircFBXW7	Glioblastoma	FBXW7-185aa	c-MYC	Inhibits proliferation and invasion	Yang et al. (2018a)
5	Circ-CDYL	HCC	miR-892a/328-3p	HDGF	Promotes cancer cell growth and propagation	Wei et al. (2020)
				HIF1AN
				PI3K/AKT
6	CircMTO1	HCC	miR-9	p21	Inhibits cancer progression	Han et al. (2017)
7	Circ-TCF25	Bladder	miR-103-3p/miR-107	CDK6	Promotes cancer progression	Zhong et al. (2016)
8	Crc-ITCH	Bladder	miR-17/miR-224	P21	Inhibits cancer progression	Yang et al. (2018b)
9	CircAmotl1	Prostate	miR-193a-5p	pcdha	Inhibition of EMT	Yang et al. (2019a)
10	Circ-Foxo3	Breast	miR-138	P53	Promotes apoptosis of cancer cells	Du et al. (2017)
11	Circ-HIAT1	Renal	miR-29c-3p/miR-195-5p/miR-29a-3p	CDC42	Promotes cancer invasion and metastasis	Wang et al. (2019)
12	CircNRIP1	Gastric	miR-149-5p	AKT/mTOR	Promotes cancer proliferation and invasion	Zhang and Zhang et al. (2019)
13	CircCCDC66	Colorectal	miR-33b/93	MYC	Promotes cancer growth, invasion, and metastasis	Hsiao et al. (2017)
14	CircPRMT5	Bladder	miR-30c	SNAIL	Promotes EMT and metastasis	Chen et al. (2018b)
15	CircUBAP2	Osteosarcoma	miR-143	Bcl-2	Promotes cancer proliferation	Zhang et al. (2017)
16	CircOMA1	Pituitary adenoma	miR-145-5p	TPT1	Inhibition of apoptosis and promotion of cancer progression	Du et al. (2019)
				Mcl-1
				Bcl-xL
17	Circ_001079	HUVEC	miR-186	HIF-1 α	Promotes cancer proliferation and angiogenesis	Dang et al. (2017)