. 2022 Jan 11;8:811809. doi: 10.3389/fvets.2021.811809

Table 1.

Effect of intra-CL injection or IM administration (positive control) of dinoprost or saline solution on oxytocin (OT) concentrations in blood plasma of cows (n = 3 per dose), on day 10 of the estrous cycle.

Time (h)	Oxytocin (ng/ml)
	Intra-CL injection				IM administration
	Saline (control)	1.25 mg dinoprost	2.5 mg dinoprost	5 mg dinoprost	Saline (control)	25 mg dinoprost
0	13.22 ± 0.1^a	11.10 ± 3.74^a	10.31 ± 1.74^a	13.78 ± 3.28^a	13.11 ± 0.06^a	8.81 ± 1.00^a
0.25	9.32 ± 4.25^a	39.09 ± 14.25^b	42.88 ± 8.08^b^,^*	53.20 ± 12.77^b^,^**	8.68 ± 4.16^a	55.80 ± 14.55^b^,^***
0.5	10.36 ± 2.59^a	43.22 ± 9.85^b^,^*	58.34 ± 7.68^b^,^***	54.80 ± 18.93^b^,^**	7.14 ± 0.69^a	67.21 ± 15.15^b^,^***
0.75	7.744 ± 0.27^a	29.78 ± 7.98^a	48.73 ± 1.98^b^,^**	62.60 ± 19.36^b^,^***	8.99 ± 1.27^a	66.98 ± 13.97^b^,^***
1	13.39 ± 2.42^a	8.39 ± 3.77^a	31.80 ± 7.20^a	9.02 ± 3.04^a	14.37 ± 1.45^a	38.09 ± 2.45^a^,^*
2	16.52 ± 4.15^a	17.33 ± 3.23^a	12.93 ± 8.26^a	23.94 ± 2.80^a	14.66 ± 4.54^a	23.72 ± 6.41^a
4	13.59 ± 1.61^a	6.79 ± 4.39^a	19.30 ± 6.37^a	16.26 ± 4.97^a	10.80 ± 3.23^a	20.67 ± 9.50^a

All OT concentration values are expressed as mean ± SEM.

Letters

^{(a, b)}

indicate simple effects within rows (treated group compared to respective control group; P < 0.05).

Asterisks

^(*

P < 0.05;

^**

P < 0.01;

^***

P < 0.001) indicate statistically significant differences vs. the period before treatment (time 0 h), in two-way interactions.