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. 2022 Jan 11;12:783975. doi: 10.3389/fimmu.2021.783975

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Copyright © 2022 Yeo, Chia, Tan, Ong, Yeo, Zhang, Poh, Lim, Sim, Sutamam, Chua, Albani, Wang and Chua

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SARS-CoV-2 spike RBD-specific antibody responses in serum over the 2-dose BNT162b2 mRNA vaccination. Median serum corrected OD₄₅₀ values over the different time points for (A) SARS-CoV-2 RBD-specific IgG1, (B) IgG3, (C) IgA and (D) IgM isotypes. Violin plots with included boxplots showing kernel probability density of corrected OD₄₅₀ with the dashed and dotted black lines representing the median and 25th/75th quartiles respectively. Comparisons of differences between time points were assessed using repeated measures mixed-effects model followed by post hoc Tukey’s multiple comparisons test. The asterisk indicates P<0.05, double asterisk indicates P<0.001, the triple asterisk indicates P<0.0001.