Table 2.

Univariate and multivariate Cox regression analysis of risk factors for 30-day mortality.

Variable	Univariate analysis			Multivariate analysis
	HR a	95%CI for HR	P value	HR	95%CI for HR	P value
Sex, male vs female	0.88	0.48-1.64	0.700
Age, y, ≥65 vs <65	2.01	1.03-3.92	0.040	2.03	0.83-4.98	0.121
Respiratory failure	3.24	1.87-5.63	<0.001	2.67	1.44-4.97	0.002
Heart failure	1.57	0.87-2.84	0.133
MODS	5.54	2.89-10.63	<0.001
SOFA, 1-point increments	1.28	1.17-1.40	<0.001	1.36	1.22-1.51	<0.001
WBC, × 109/L
4-10 vs <4	0.29	0.10-0.82	0.020
≥10 vs <4	0.64	0.25-1.65	0.358
Hemoglobin, g/L, <80 vs ≥80	1.96	1.13-3.41	0.017
Platelet, × 109/L, <100 vs ≥100	3.11	1.76-5.49	<0.001
CRP, mg/L, ≥150 vs <150	1.88	1.04-3.39	0.036
PCT, ng/mL, ≥5 vs <5	4.59	2.39-8.83	<0.001	3.54	1.82-6.86	<0.001
Albumin, g/L, <30 vs ≥30	4.1	2.30-7.31	<0.001
Tigecycline	1.69	0.98-2.94	0.061
Aminoglycosides	0.32	0.12-0.89	0.029
Fosfomycin	0.36	0.15-0.84	0.018
Number of anti-KP drugs
2 vs 1	0.76	0.41-1.41	0.389
3 vs 1	0.38	0.16-0.88	0.024
Appropriate treatments in 3 days	0.48	0.27-0.83	0.008	0.33	0.17-0.63	<0.001

^aHRs were calculated comparing with comorbidity and without comorbidity.

CI, confidence interval; HR, hazard ratio; MODA, multiple organ dysfunction syndrome; SOFA, Sequential Organ Failure Assessment; WBC, white blood count; CRP, c-reactive protein; PCT, procalcitonin; KP, Klebsiella pneumonia.