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Translational control by ISG-RBPs. (A) Upon viral infection, several ISGs (such as PKR, ZAP and IFIT1) suppress viral and/or cellular translation by recognizing different RNA sequences or structures and targeting important initiation and elongation factors. With PARP12, PKR and ZAP also participate in stress granule mediated antiviral response (227, 230–232). (B) 2’O methylation of cellular mRNAs recruits CMTR1 that inhibits IFIT1 mediated translation repression (233, 234).
