FIGURE 5.

Key functional imaging studies of cerebrocerebellar interaction. (A) Voxel-to-network mapping of cerebellar relationship to cerebral intrinsic networks. Most of the cerebellum is most-strongly linked to association and cognitive cerebral areas. (B) Co-activation pattern analysis identifies recurring spatial patterns of co-activation in the brain. Left: three unique cerebral co-activation patterns involving the intraparietal sulcus are shown. Lower panel shows unique thalamic foci associated with each pattern as well. Right: corresponding cerebellar activations. Focal activation of cerebellar cortex is linked to complex patterns of co-activation across distributed cerebral cortical networks. The non-overlapping foci suggests a voxel-to-network mapping of cerebellar activity to cortical networks is insufficient to describe the cerebellum’s role in distributed brain networks. (C) Maturation of brain networks over the course of development. Black arrow indicates cluster of cerebellar nodes at each developmental stage. Early in development, cortical areas are functionally linked to their nearest anatomical neighbors, and the cerebellum has no functional link to the cortex. Once mature however, the cerebellum acts as a hub between distributed functional networks in cortex.