TABLE 5.

Candidate SNP loci corresponding genes and associated interactions with selenium and T-2 toxin.

SNP loci	Gene name	Associated chemicals	Interactions from the CTD database	References: Pubmed ID
rs12629751	PPARG	Selenium	PPARG protein promotes the reaction [Selenium inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]]	17439952
			Selenium promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of PPARG protein]	17439952
		Sodium selenite	Sodium selenite inhibits the reaction [2-cresol results in increased expression of PPARG mRNA]	21705299
			Sodium selenite results in increased expression of PPARG protein	24140496
		T-2 toxin	T-2 toxin results in increased expression of PPARG mRNA	26141394
rs1800796	IL6	Selenium	[Cadmium analog co-treated with selenium analog co-treated with zinc sulfide analog] results in increased expression of IL6 mRNA	21481475
			Selenium affects the reaction [mercuric chloride results in decreased expression of IL6 protein]	26089086
		Sodium selenite	[Sodium selenite co-treated with plant extracts] inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]	26085057
			Sodium selenite inhibits the reaction [cadmium chloride results in increased expression of IL6 protein]	24954678
			Sodium selenite inhibits the reaction [IL6 protein results in increased activity of AR protein]	17346688
			Sodium selenite inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]	17346688
			Sodium selenite inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]	26085057
			Sodium selenite inhibits the reaction [TGFB1 protein results in increased expression of IL6 protein]	16757516
			Sodium selenite results in increased expression of IL6 mRNA	18175754
		T-2 toxin	AKNA protein affects the reaction [T-2 toxin results in increased expression of IL6 mRNA]	29079362
			Alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 toxin results in increased expression of IL6 mRNA]	22454431
			Stattic inhibits the reaction [T-2 toxin results in increased expression of IL6 mRNA]	22454431
			T-2 toxin results in increased expression of IL6 mRNA	29079362
rs1871054	ADAM12	Sodium selenite	Sodium selenite results in decreased expression of ADAM12 mRNA	18175754
rs6494629	SMAD3	Sodium selenite	Sodium selenite results in increased expression of SMAD3 mRNA	18175754
rs4789936	TIMP2	Selenium	Selenium inhibits the reaction [T-2 toxin results in decreased expression of TIMP2 protein]	21144892
			Selenium results in decreased expression of TIMP2 mRNA	17390030
		T-2 toxin	Selenium inhibits the reaction [T-2 toxin results in decreased expression of TIMP2 protein]	21144892
			T-2 toxin affects the expression of TIMP2 mRNA	21112371
			T-2 toxin results in decreased expression of TIMP2 protein	21144892

Note: CTD, is short for Comparative Toxicogenomics Database.