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. 2022 Jan 11;11:715077. doi: 10.3389/fonc.2021.715077

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Copyright © 2022 de Geus, Ewing-Graham, de Koning, de Koning, van den Bosch, Nigg, van Eijck, Jozwiak, van Beekhuizen and Mustafa

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression alterations in cervix tumors. Volcano plots showing over- and underexpressed genes in cervix tumors. Each dot represents a gene of the nCounter^® PanCancer IO 360 Gene Expression Panel. Y-axis: p-values after the Benjamini-Hochberg procedure (-log10 scale). X-axis: Fold of change is calculated with healthy controls as baseline reference (log2 ratio). (A) CCNR vs. healthy controls. (B) CCLR vs. healthy controls. (C) CCDR vs. healthy controls. (D) Venn diagram showing differentially overexpressed genes in CCNR, CCLR, CCNR relative to healthy controls. CCNR, Cervical cancer no recurrence; CCLR, Cervical cancer local recurrence; CCDR, Cervical cancer distant recurrence.