Table 1.
Clinicopathological characteristics.
CCLR (n = 14) | CCDR (n = 8) | CCNR (n = 12) | p-valuea | |
---|---|---|---|---|
Age | 45.6 [32 – 69] | 47.6 [37 – 60] | 42.4 [32 – 61] | 0.51 |
Histology | 0.12 | |||
Squamous cell carcinoma | 8 (57.1) | 7 (87.5) | 5 (41.7) | |
Adenocarcinoma | 6 (42.9) | 1 (12.5) | 7 (68.3) | |
Surgical approach | <0.01 | |||
Laparotomy | 14 (100.0) | 8 (100.0) | 3 (25.0) | |
Robot-assisted | 0 (0.0) | 0 (0.0) | 9 (75.0) | |
LVSI | 0.11 | |||
Yes | 6 (42.9) | 7 (87.5) | 6 (50.0) | |
No | 8 (57.1) | 1 (12.5) | 6 (50.0) | |
TNM stage, post-operative | <0.01 | |||
T1B1 N0 M0 | 14 (100) | 2 (25.0) | 12 (100) | |
T1B1 N1 M0 | 0 (0) | 6 (75.0) | 0 (0) | |
Adjuvant therapy | <0.01 | |||
Not indicated | 12 (85.7) | 0 (0.0) | 10 (83.3) | |
Radiotherapy | 2 (14.3) | 6 (75.0) | 2 (17.7) | |
Chemoradiation | 0 (0.0) | 2 (25.0) | 0 (0.0) | |
HPV subtype | ||||
HPV-16 | 9* (69.2) | 5 (62.5) | 8 (66.7) | |
HPV-18 | 2 (15.4) | 2 (25.0) | 3 (25.0) | |
Other high-risk HPV | – | 1 (12.5) | 1 (8.3) | |
No HPV | 2 (15.4) | – | – | |
Time to recurrence, months | 17 [7-139] | 39 [10-90] | 0.48 | |
Disease status last follow-up | <0.01 | |||
Alive, no evidence of disease | 9 (64.3) | 3 (37.5) | 12 (100) | |
Dead with disease | 5 (36.7) | 5 (62.5) | 0 (0) |
Values are presented as numbers (%) or mean [range]. The numbers in bold are statistically significant. CCLR, Cervical cancer local recurrence; CCDR, Cervical cancer distant recurrence; CCNR, Cervical cancer no recurrence; FIGO, International Federation of Gynaecology and Obstetrics; LVSI, lymphovascular space invasion; TNM, Tumour Node Metastasis Classification of Malignant tumors. a Represents the P value between CCLR vs. CCDR vs. CCNR and the value in bold indicates a significant difference between the groups (p<0.05). *One patient was infected with both HPV-16 and HPV-18.
aRepresents the p-value between CCLR vs. CCDR vs. CCNR and the value in bold indicates a significant difference between the groups (p < 0.05).