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. 2022 Jan 11;11:715077. doi: 10.3389/fonc.2021.715077

Table 1.

Clinicopathological characteristics.

CCLR (n = 14) CCDR (n = 8) CCNR (n = 12) p-valuea
Age 45.6 [32 – 69] 47.6 [37 – 60] 42.4 [32 – 61] 0.51
Histology 0.12
Squamous cell carcinoma 8 (57.1) 7 (87.5) 5 (41.7)
Adenocarcinoma 6 (42.9) 1 (12.5) 7 (68.3)
Surgical approach <0.01
Laparotomy 14 (100.0) 8 (100.0) 3 (25.0)
Robot-assisted 0 (0.0) 0 (0.0) 9 (75.0)
LVSI 0.11
Yes 6 (42.9) 7 (87.5) 6 (50.0)
No 8 (57.1) 1 (12.5) 6 (50.0)
TNM stage, post-operative <0.01
T1B1 N0 M0 14 (100) 2 (25.0) 12 (100)
T1B1 N1 M0 0 (0) 6 (75.0) 0 (0)
Adjuvant therapy <0.01
Not indicated 12 (85.7) 0 (0.0) 10 (83.3)
Radiotherapy 2 (14.3) 6 (75.0) 2 (17.7)
Chemoradiation 0 (0.0) 2 (25.0) 0 (0.0)
HPV subtype
HPV-16 9* (69.2) 5 (62.5) 8 (66.7)
HPV-18 2 (15.4) 2 (25.0) 3 (25.0)
Other high-risk HPV 1 (12.5) 1 (8.3)
No HPV 2 (15.4)
Time to recurrence, months 17 [7-139] 39 [10-90] 0.48
Disease status last follow-up <0.01
Alive, no evidence of disease 9 (64.3) 3 (37.5) 12 (100)
Dead with disease 5 (36.7) 5 (62.5) 0 (0)

Values are presented as numbers (%) or mean [range]. The numbers in bold are statistically significant. CCLR, Cervical cancer local recurrence; CCDR, Cervical cancer distant recurrence; CCNR, Cervical cancer no recurrence; FIGO, International Federation of Gynaecology and Obstetrics; LVSI, lymphovascular space invasion; TNM, Tumour Node Metastasis Classification of Malignant tumors. a Represents the P value between CCLR vs. CCDR vs. CCNR and the value in bold indicates a significant difference between the groups (p<0.05). *One patient was infected with both HPV-16 and HPV-18.

aRepresents the p-value between CCLR vs. CCDR vs. CCNR and the value in bold indicates a significant difference between the groups (p < 0.05).