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. 2022 Jan 11;12:808228. doi: 10.3389/fpls.2021.808228

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Copyright © 2022 Wang, Tong, Adejobi, Wang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The biosynthetic pathway for terpenoid indole alkaloids in Dendrobium officinale. The alkaloid biosynthesis contains the precursor formation from the shikimate, MEP, and MVA pathways and the alkaloid pathway. 2P-CDP-MEP, 2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol; 3I-GP, (3-indoyl)-glycerolphosphate; 3P-SH, shikimate 3-phosphate; 5P-CPDRC, 1-(2-carboxyphenylamino)-1′-deoxy-D-ribulose 5-phosphate; CDP-MEP, 4-(cytidine 5′-diphoshpo)-2-C-methyl-D-erythritol; cMEPP, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate; CV-5P-SH, 5-O-(1-carboxyvinyl)-3-phosphoshikimate; DDAH, 7P-2-dehydro-3-deoxy-D-arabino-heptonate; DMAPP, dimethylallyl-PP; DQ, 3-dehydroquinate; DSH, 3-dehydroshikimate; DXP, 1-deoxy-D-xylulose-5-phosphate; EP, D-erythrose 4-phosphate; HMBPP, 1-hydroxy-2-methyl-2-butenyl-4-diphosphate; HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA; IPP, isopentenyl-PP; MEP, 2-C-methyl-D-erythritol-4-phosphate; PPV, phosphoenolpyruvate; PRA, N-(5-phospho-β-D-ribosyl)-anthranilate; 7-DLH, 7-deoxyloganate 7-hydroxylase; AACT, acetyl-CoA acetyltransferase; AS, anthranilate synthase; CMK, 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; CMS, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; CPR, NADPH-hemoprotein reductase; CS, chorismate synthase; DHQ, 3-dehydroquinate dehydratase; DHQS, 3-dehydroquinate synthase; DHS, 3-deoxy-7-phosphoheptulonate synthase; DHy, dehydrogenase; DXR, 1-deoxy-D-xylulose-5-phosphate reductoisomerase; DXS, 1-deoxyxylulose-5-phosphate synthetase; EPSPS, 3-phosphoshikimate 1-carboxyvinyltransferase; G10H, geraniol 10-hydroxylase; G8H, geraniol 8-hydroxylase; GPP, geranyl diphosphate diphosphatase; GES, geranyl diphosphate synthase; GS, geissoschizine synthase; HD, hydroxylase; HDR, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase; HDS, 1-hydroxy-2-methyl-2-(E)-butenyl-4- diphosphate synthase; HMGR, HMG-CoA reductase; HMGS, HMG-CoA synthase; IGPS, indole-3-glycerolphosphate synthase; IPI, IPP isomerase; LAMT, loganate O-methyltransferase; MCS, 2-C-methyl-D-erythritol 2,4- cyclodiphosphate synthase; MPDC, mevalonate diphosphate decarboxylase; MVK, mevalonate kinase; PMK, phosphomevalonate kinase; PNAE, polyneuridine-aldehyde esterase; PRAI, phosphoribosylanthranilate isomerase; QSDH, quinate/shikimate dehydrogenase; SCS, secologanin synthase; SG, strictosidine β-D-glucosidase; SK, shikimate kinase; SKDH, shikimate dehydrogenase; STR, strictosidine synthase; TDC, tryptophan decarboxylase; TrpD, anthranilate phosphoribosyltransferase; TSB, tryptophan synthase; UGT8, 7-deoxyloganetic acid glucosyltransferase; VS, vinorine synthase.