Table 3.
Value of urine IL-18, NGAL, KIM-1 levels and combined detection for early diagnosis of AKI.
| Variables | The optimum cutoff value | AUC (95% CI) | Sensitivity | Specificity |
|---|---|---|---|---|
| IL-18 (pg/mL) | ||||
| 4 h | 16.73 | 0.681 (0.594–0.769) | 0.661 | 0.695 |
| 12 h | 26.44 | 0.881 (0.815–0.947) | 0.786 | 0.947 |
| 24 h | 30.08 | 0.859 (0.795–0.923) | 0.679 | 0.927 |
| 48 h | 28.31 | 0.822 (0.753–0.892) | 0.768 | 0.768 |
| NGAL (ng/mL) | ||||
| 4 h | 984.41 | 0.578 (0.482–0.674) | 0.286 | 0.947 |
| 12 h | 1110.62 | 0.681 (0.585–0.777) | 0.375 | 0.987 |
| 24 h | 945.00 | 0.677 (0.580–0.774) | 0.500 | 0.881 |
| 48 h | 989.69 | 0.671 (0.575–0.768) | 0.518 | 0.861 |
| KIM-1 (pg/mL) | ||||
| 4 h | 24.12 | 0.721 (0.629–0.813) | 0.571 | 0.874 |
| 12 h | 33.39 | 0.968 (0.937–0.996) | 0.946 | 0.907 |
| 24 h | 36.23 | 0.967 (0.94–0.989) | 0.893 | 0.940 |
| 48 h | 32.86 | 0.947 (0.913–0.982) | 0.929 | 0.854 |
| IL-18+ NGAL+ KIM-1 4 h | – | 0.779 (0.699–0.859) | 0.696 | 0.775 |
| IL-18+ NGAL+ KIM-1 12 h | – | 0.997 (0.991–0.998) | 0.982 | 0.967 |
IL-18: interleukin-18; NGAL: neutrophil gelatinase-associated lipocalin; KIM-1: kidney injury molecule-1; AKI: acute kidney injury; AUC: area under curve; CI: confidential interval.