Fig. 2.

STING1-mediated type I IFNs and inflammatory cytokines in sepsis. During sepsis, activated STING1 recruits and phosphorylates TBK1, which further activates IRF3- and NF-κB-dependent type I IFN and inflammatory cytokine production. Meanwhile, activated TBK1 could promote phosphorylation and secretion of SQSTM1, which further activates NF-κB.

Abbreviations: DIC: disseminated intravascular coagulation; IRF3: interferon regulatory factor 3; NF-κB: nuclear factor kappa B complex; SQSTM1: sequestosome 1; STING1: stimulator of interferon response cGAMP interactor 1; TBK1: TANK binding kinase 1.