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. 2021 Jul 19;25(1):1–10. doi: 10.1016/j.cjtee.2021.07.009

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — STING1-mediated pyroptosis in sepsis. During sepsis, activated STING1 triggers Ca²⁺-mediated pyroptosis in macrophages, leading to F3 release and coagulation. However, STING1 also activates IRF3/NLRP3 axis-mediated CASP1-dependent pyroptosis in cardiomyocytes, leading to cardiovascular dysfunction.

Abbreviations: Ca²⁺: calcium; CASP: caspase; DIC: disseminated intravascular coagulation; F3: coagulation factor III; IRF3: interferon regulatory factor 3; NLRP3: NLR family pyrin domain containing 3; STING1: stimulator of interferon response cGAMP interactor 1.