Table 1.
Baseline Characteristics for Patients with One Event and More Than One Event
| 1 Event |
>1 Event |
Total (n = 198) | |||
|---|---|---|---|---|---|
| Inhaled Treprostinil (n = 54) | Placebo (n = 51) | Inhaled Treprostinil (n = 35) | Placebo (n = 58) | ||
| Female, n (%) | 28 (52%) | 19 (37%) | 18 (51%) | 28 (48%) | 93 (47%) |
| Age, yr, mean (SD) | 64 (14) | 68 (11) | 68 (11) | 67 (11) | 67 (12) |
| White, n (%) | 39 (72%) | 42 (82%) | 24 (69%) | 42 (72%) | 147 (74%) |
| BMI, kg/m2, mean (SD) | 30.2 (7.4) | 28.9 (6.3) | 29.7 (5.7) | 27.9 (5.4) | 29.1 (6.3) |
| Years since PH-ILD diagnosis, mean (SD) | 0.5 (0.7) | 0.3 (0.3) | 0.6 (1.2) | 0.7 (1.3) | 0.5 (1.0) |
| Disease etiology, n (%) | |||||
| IIP | 25 (46%) | 29 (57%) | 11 (31%) | 26 (45%) | 91 (46%) |
| IPF only | 16 (30%) | 20 (39%) | 7 (20%) | 16 (28%) | 59 (30%) |
| CPFE | 11 (20%) | 7 (14%) | 12 (34%) | 17 (29%) | 47 (24%) |
| CTD-ILD | 16 (30%) | 11 (22%) | 6 (17%) | 13 (22%) | 46 (23%) |
| 6-min-walk distance, m, mean (SD) | 247 (99) | 273 (89) | 211 (80) | 235 (92) | 244 (93) |
| NT-proBNP, pg/ml, mean (SD) | 1,991 (3,349) | 931 (1,257) | 2,431 (2,985) | 3,130 (4,382) | 2,123 (3,343) |
| Hemodynamics, mean (SD) | |||||
| PAPm, mm Hg | 38.4 (9.8) | 35.0 (7.9) | 38.8 (9.7) | 37.1 (8.9) | 37.2 (9.1) |
| PCWP, mm Hg | 10.6 (3.4) | 9.8 (3.1) | 10.4 (3.7) | 9.9 (3.8) | 10.1 (3.5) |
| PVR, Wood units | 6.5 (3.2) | 5.6 (2.2) | 6.7 (2.5) | 6.6 (3.3) | 6.4 (2.9) |
| Lung function tests, mean (SD) | |||||
| TLC % predicted | 62 (16) | 65 (21) | 62 (18) | 65 (16) | 63 (16) |
| FVC % predicted | 60 (19) | 63 (22) | 61 (19) | 63 (20) | 62 (20) |
| FEV1% predicted | 61 (19) | 65 (21) | 61 (20) | 65 (20) | 63 (20) |
| DlCO % predicted | 30 (12) | 29 (10) | 29 (13) | 25 (13) | 28 (12) |
Definition of abbreviations: BMI = body mass index; CPFE = combined pulmonary fibrosis and emphysema; CTD-ILD = connective tissue disease–associated interstitial lung disease; IIP = idiopathic interstitial pneumonia; IPF = idiopathic pulmonary fibrosis; NT-proBNP = N-terminal pro–brain natriuretic peptide; PAPm = mean pulmonary arterial pressure; PCWP = pulmonary capillary wedge pressure; PH-ILD = interstitial lung disease complicated by pulmonary hypertension; PVR = pulmonary vascular resistance.