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. 2022 Jan 11;11:774558. doi: 10.3389/fonc.2021.774558

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Copyright © 2022 Xing, Yin, Yao and Xing

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of prognostic signatures based on FR-DEGs, IR-DEGs, and FI-DEGs. (A–D) Optimal cutoff value (A), distribution of the CIFI values (up) and survival status (down) (B), overall survival curves (C), and PCA plot (D) of the prognosis model constructed by three FR-DEGs. (E–H) Optimal cutoff value (E), distribution of the CIFI values (up) and survival status (down) (F), overall survival curves (G), and PCA plot (H) of the prognosis model constructed by six IR-DEGs. (I–L) Optimal cutoff value (I), distribution of the CIFI values (up) and survival status (down) (J), overall survival curves (K), and PCA plot (L) of the prognosis model constructed by eight FI-DEGs. DEGs, differentially expressed genes; FR-DEGs, ferroptosis-related DEGs; IR-DEGs, immune-related DEGs; FI-DEGs, ferroptosis- and immune-related DEGs; CIFI, comprehensive index of ferroptosis and immune status; PCA, principal component analysis.