TABLE 1.
The role of RNA m6A modification in bladder cancer.
| Type | m6A regulator | Role in cancer | Biological function | Mechanism | References |
|---|---|---|---|---|---|
| m6A writer | METTL3 | Oncogene | Promotes cell growth and invasion | METTL3/AFF4/NF-κB/MYC | Lan et al. (2020) |
| METTL3 | Oncogene | Promotes malignant transformation and tumorigenesis | METTL3-m6A-CDCP1 | Purslow et al. (2021) | |
| METTL3 | Oncogene | Promotes cell proliferation | METTL3-DGCR8-PTEN | Chen et al. (2021b) | |
| METTL3/pri-miR221/222 | |||||
| METTL3 | Oncogene | Promotes cancer proliferation and metastasis | METTL3/YTHDF2/SETD7/KLF4 | Wu et al. (2021) | |
| METTL3 | Oncogene | Promotes bladder cancer development | METTL3-m6A-CDCP1 | Wollen et al. (2021) | |
| METTL3 | Oncogene | Promotes oncogenesis and tumor angiogenesis | METTL3/TEK/VEGF-A | Esteve-Puig et al. (2021) | |
| METTL3 | Oncogene | Promotes tumor proliferation and metastasis | cisplatin/METTL3/G-CSF | Niu et al. (2019) | |
| METTL14 | Tumor suppressor | Inhibits the proliferation, self-renewal, metastasis and tumor initiating capacity of bladder TICs | METTL14/m6A/NOTCH1 | Cui et al. (2021) | |
| METTL14 | Tumor suppressor | Inhibits cell invasion | ISO/FOXO3a/METTL14/Vimentin | Nie et al. (2021) | |
| m6A eraser | FTO | Tumor suppressor | Inhibits cell proliferation and invasion | — | Li et al.(2021b) |
| FTO | Oncogene | Promotes cancer initiation and progression | UPS18/FTO/PYCR1 | Dai et al. (2021) | |
| FTO | Oncogene | Stimulates cell viability and tumorigenicity | FTO/MALAT/miR-384/MAL2 | Tsuchiya et al. (2021) | |
| ALKBH5 | Tumor suppressor | Inhibits bladder cancer growth and progression | ALKBH5/ITGA6/YTHDF1/3 | Terajima et al. (2021) | |
| ALKBH5 | Tumor suppressor | Inhibits cell proliferation, migration, invasion and increases cisplatin chemosensitivity | ALKBH5/m6A/CK2a | Xu et al. (2021) | |
| m6A reader | YTHDF1/3 | Oncogene | Promotes bladder cancer growth and progression | METTL3/ITGA6/YTHDF1/3 | Hu et al. (2021) |
| YTHDF2 | Oncogene | Promotes cancer proliferation and metastasis | METTL3/YTHDF2/SETD7/KLF4 | Chang et al. (2021) | |
| IGF2BP1 | Oncogene | Promotes bladder cancer cell invasion, metastasis and cell cycle progression | circPTPRA/IGF2BP1/FSCN1- MYC | Hou et al. (2021) | |
| IGF2BP3 | Oncogene | Promotes cell proliferation, cell cycle and inhibit apoptosis | IGF2BP3/JAK/STAT | Kim and Siddiqui (2021) |