TABLE 2.

Bidirectional MR results between HF and AD.

Methods	Influence of AD traits on HF			Influence of HF traits on AD
	OR (95%CI)	Beta	P	OR (95%CI)	Beta	p
IVW	0.985 (0.945, 1.026)	−0.015	0.471	0.848 (0.702,1.025)	−0.165	0.088
MR-Egger	0.982 (0.913, 1.056)	−0.018	0.633	0.665 (0.380,1.161)	−0.409	0.195
Weighted median	0.977 (0.932, 1.025)	−0.023	0.337	0.759 (0.596,0.967)	−0.275	0.025
Simple mode	0.970 (0.898, 1.047)	−0.03	0.454	0.729 (0.483,1.100)	−0.317	0.21
Weighted mode	0.978 (0.932, 1.028)	−0.022	0.401	0.722 (0.505,1.031)	−0.326	0.182

AD, Alzheimer’s disease; HF, heart failure; p, p-value; IVW, inverse variance weighted.