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. 2022 Jan 11;12:796812. doi: 10.3389/fgene.2021.796812

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Copyright © 2022 Shen, Zhou, Liu, Yang, Huang, Yu and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The PPI network and two cluster modules were extracted by mCODE. (A) The PPI network of DEGs in GSE23289, which comprised 167 nodes and 334 edges. Each node represents a protein, while each edge between the two proteins shows a protein–protein correlation. The up- or downregulated genes are highlighted as red circles and blue diamonds, respectively. (B) Cluster mCODE 1 consists of 10 nodes and 21 edges. mCODE score = 4.667. KLHL21 is the seed gene in this subnetwork. (C) Cluster mCODE 2 includes five nodes and nine edges. mCODE score = 4.5. DNAJB9 is the seed gene in this subnetwork. (D) Cluster mCODE 3 includes four nodes and six edges, MT1M is the seed gene, score = 4. (E) Cluster mCODE 4 includes 17 nodes and 31 edges, ZFP36 is the seed gene, and score = 3.882).