Table 1.

MicroRNAs therapy.

MicroRNA	Source and methodologies	Effects
MiR-133b	Extraneous: lentiviral delivery	Downregulate the expression of chondroitin sulfate proteoglycans, RhoA and inhibit microglia/macrophage proliferation (115)
MiR-124	Extraneous: cell transfection	Reduced proinflammatory molecules (116)
MiR-873a-5p	Endogenous: astrocyte-derived exosomes	Reduce inflammatory cytokines, increase anti-inflammatory factors (117)
MiR-34a	Extraneous: intrathecal injection	Reduce inflammatory cytokines secretion of microglia, promote neural recovery and locomotor function (118)
MiR-150	Extraneous: cell transfection	Decrease the expression of pro-inflammatory cytokines (119)
MiR-216a-5p	Endogenous: MSC-derived exosomes	Switching microglial phenotype to secret anti-inflammatory molecules (111)
MiR-340-5p	Extraneous: cell transfection	Attenuate inflammation, oxidative stress, and apoptosis (120)
MiR-23b	Extraneous: cell transfection	Inhibited the BV-2 cells apoptosis and NF-κB activation (121)
MiR-193a antagomir	Extraneous: cell transfection	Reduced expression of neuroinflammatory molecules (122)
miR-429 inhibitors	Extraneous: cell transfection	Reduced expression of neuroinflammatory molecules (123)
MiR-223-5p inhibitor	Extraneous: intrathecal injection	Reduced expression of neuroinflammatory molecules, reduced neuron apoptosis and promoted locomotor recovery (124)
MiR27a	Extraneous: cell transfection	Alleviate apoptosis and inflammatory injury (125)
MiR100	Extraneous: cell transfection and intrathecal injection	Suppresses microglia activation and neuronal apoptosis (126)
MiR-183	Extraneous: intracerebroventrivular injection	Inhibits microglia activation and expression of inflammatory factors (127)