Figure 8.

Schematic figure of the underlying mechanisms of mesopore size regulating clot‐immune responses and the strategies to develop clot‐immune regulatory biomaterials. A) Mesopore size below 9 nm has little impact on fibrin formation and the following biological activities of cell. Mesopore size above 9 nm induces thinner fibers and smaller contact area with cells, which reduces inflammatory response via pathway of the cell adhesion‐cytoskeleton assembly‐inflammatory response. B) The development strategy diagram of clot‐immune regulatory materials by tuning fibrin network parameters including fiber thickness, fibrin porosity, density, mechanical strength, and degradation pattern.