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Schematic representation of tamoxifen biotransformation into primary and secondary metabolites by the cytochrome P540 system. The thickness of the arrows represents the relative contribution of each of the pathway to the overall oxidation of tamoxifen. Reprinted from Sideras et al. J Clin Oncol. 2010;28(16):2768-2776, with permission from Wolters Kluwer Health, Inc.
