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. 2021 Nov 26;9(3):2103631. doi: 10.1002/advs.202103631

Table 3.

GO Terms for NP subpopulations

Efector NPCs GO terms
GOID GOTerm P‐value
GO:0016126 sterol biosynthetic process 2.432 × 10−11
GO:0006695 cholesterol biosynthetic process 5.795 × 10−10
GO:0030198 extracellular matrix organization 3.136 × 10−8
GO:0044281 small molecule metabolic process 4.528 × 10−8
GO:0001558 regulation of cell growth 2.285 × 10−6
GO:0001501 skeletal system development 3.133 × 10−6
GO:0006694 steroid biosynthetic process 5.308 × 10−6
GO:0008203 cholesterol metabolic process 9.283 × 10−6
GO:0008202 steroid metabolic process 1.061 × 10−5
GO:0006048 UDP‐N‐acetylglucosamine biosynthetic process 1.904 × 10−5
GO:0008299 isoprenoid biosynthetic process 2.17 × 10−5
GO:0010628 positive regulation of gene expression 3.007 × 10−5
GO:0008285 negative regulation of cell proliferation 3.96 × 10−5
GO:0009405 pathogenesis 5.295 × 10−5
GO:0072593 reactive oxygen species metabolic process 6.08 × 10−5
GO:0006629 lipid metabolic process 9.184 × 10−5
GO:0048661 positive regulation of smooth muscle cell proliferation 9.297 × 10−5
GO:0033173 calcineurin‐NFAT signaling cascade 0.0001037
GO:0030199 collagen fibril organization 0.0001053
GO:0042127 regulation of cell proliferation 0.0001366
GO:0001525 angiogenesis 0.0001439
GO:0014070 response to organic cyclic compound 0.0001497
GO:0010955 negative regulation of protein processing 0.0001541
GO:0042340 keratan sulfate catabolic process 0.0001541
GO:0006011 UDP‐glucose metabolic process 0.0001563
GO:0007568 aging 0.0001871
GO:0006633 fatty acid biosynthetic process 0.0002058
GO:0043434 response to peptide hormone 0.000223
GO:0055114 oxidation‐reduction process 0.0002321
GO:0005975 carbohydrate metabolic process 0.0003237
GO:0043065 positive regulation of apoptotic process 0.0003622
GO:0030203 glycosaminoglycan metabolic process 0.0003728
GO:0043066 negative regulation of apoptotic process 0.000445
GO:0003331 positive regulation of extracellular matrix constituent secretion 0.0004652
GO:0006065 UDP‐glucuronate biosynthetic process 0.0004652
GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor 0.0004652
GO:0042542 response to hydrogen peroxide 0.0004732
GO:0032270 positive regulation of cellular protein metabolic process 0.0005055
GO:0006915 apoptotic process 0.0006357
GO:0010035 response to inorganic substance 0.0006375
GO:0008284 positive regulation of cell proliferation 0.0006802
GO:0044255 cellular lipid metabolic process 0.0007222
GO:0060591 chondroblast differentiation 0.0009226
GO:1903169 regulation of calcium ion transmembrane transport 0.0009226
GO:0006933 negative regulation of cell adhesion involved in substrate‐bound cell migration 0.0009226
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway 0.0009226
GO:0009314 response to radiation 0.0009242
GO:0060291 long‐term synaptic potentiation 0.0010297
GO:0045444 fat cell differentiation 0.0013192
GO:0031394 positive regulation of prostaglandin biosynthetic process 0.001525
FibroNPCs GO terms
GOID GOTerm P‐value
GO:0030198 extracellular matrix organization 8.663 × 10−42
GO:0007155 cell adhesion 9.642 × 10−28
GO:0022617 extracellular matrix disassembly 1.776 × 10−23
GO:0030574 collagen catabolic process 5.312 × 10−19
GO:0007411 axon guidance 2.226 × 10−16
GO:0030199 collagen fibril organization 8.14 × 10−16
GO:0001525 angiogenesis 1.304 × 10−12
GO:0002576 platelet degranulation 1.732 × 10−11
GO:0030168 platelet activation 9.024 × 10−11
GO:0007507 heart development 1.504 × 10−10
GO:0006928 cellular component movement 2.848 × 10−10
GO:0007596 blood coagulation 2.876 × 10−9
GO:0008285 negative regulation of cell proliferation 7.397 × 10−9
GO:0016477 cell migration 3.908 × 10−7
GO:0001558 regulation of cell growth 4.529 × 10−7
GO:0009612 response to mechanical stimulus 6.42 × 10−7
GO:0048010 vascular endothelial growth factor receptor signaling pathway 1.441 × 10−6
GO:0051017 actin filament bundle assembly 1.628 × 10−6
GO:0001649 osteoblast differentiation 2.019 × 10−6
GO:0001666 response to hypoxia 2.039 × 10−6
GO:0008283 cell proliferation 2.174 × 10−6
GO:0035987 endodermal cell differentiation 3.631 × 10−6
GO:0007162 negative regulation of cell adhesion 3.942 × 10−6
GO:0007160 cell‐matrix adhesion 4.348 × 10−6
GO:0030336 negative regulation of cell migration 4.63 × 10−6
GO:0051764 actin crosslink formation 5.041 × 10−6
GO:0071230 cellular response to amino acid stimulus 5.525 × 10−6
GO:0050900 leukocyte migration 6.418 × 10−6
GO:0048013 ephrin receptor signaling pathway 7.117 × 10−6
GO:0030335 positive regulation of cell migration 7.697 × 10−6
GO:0001974 blood vessel remodeling 8.644 × 10−6
GO:0016525 negative regulation of angiogenesis 9 × 10−6
GO:0001501 skeletal system development 9.137 × 10−6
GO:0071305 cellular response to vitamin D 1.097 × 10−5
GO:0010811 positive regulation of cell‐substrate adhesion 1.102 × 10−5
GO:0045669 positive regulation of osteoblast differentiation 1.291 × 10−5
GO:0048813 dendrite morphogenesis 1.394 × 10−5
GO:0051493 regulation of cytoskeleton organization 1.57 × 10−5
GO:0042060 wound healing 1.585 × 10−5
GO:0009611 response to wounding 1.821 × 10−5
GO:0006936 muscle contraction 2.038 × 10−5
GO:0006987 activation of signaling protein activity involved in unfolded protein response 2.151 × 10−5
GO:0043491 protein kinase B signaling 2.758 × 10−5
GO:0046718 viral entry into host cell 3.305 × 10−5
GO:0001938 positive regulation of endothelial cell proliferation 3.468 × 10−5
GO:0032964 collagen biosynthetic process 3.531 × 10−5
GO:0060674 placenta blood vessel development 3.762 × 10−5
GO:0031532 actin cytoskeleton reorganization 5.90377 × 10−5
GO:0006898 receptor‐mediated endocytosis 6.00706 × 10−5
GO:0030036 actin cytoskeleton organization 6.00706 × 10−5
Homestatic NPs GO terms
GOID GOTerm P‐value
GO:0006614 SRP‐dependent cotranslational protein targeting to membrane 2.963 × 10−89
GO:0006415 translational termination 4.999 × 10−86
GO:0006414 translational elongation 7.153 × 10−80
GO:0019083 viral transcription 1.067 × 10−76
GO:0006412 translation 1.077 × 1076
GO:0000184 nuclear‐transcribed mRNA catabolic process, nonsense‐mediated decay 5.322 × 10−75
GO:0019058 viral life cycle 9.812 × 10−75
GO:0006413 translational initiation 1.227 × 10−74
GO:0016070 RNA metabolic process 1.437 × 10−71
GO:0016071 mRNA metabolic process 3.898 × 10−67
GO:0010467 gene expression 9.55 × 10−63
GO:0016032 viral process 4.056 × 10−53
GO:0044267 cellular protein metabolic process 3.626 × 10−47
GO:0022904 respiratory electron transport chain 2.26 × 10−21
GO:0044237 cellular metabolic process 1.722 × 10−18
GO:0002181 cytoplasmic translation 5.217 × 10−15
GO:0042274 ribosomal small subunit biogenesis 1.254 × 10−11
GO:0000027 ribosomal large subunit assembly 1.824 × 10−11
GO:0000028 ribosomal small subunit assembly 2.147 × 10−10
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP‐dependent 1.431 × 10−9
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 2.655 × 10−9
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 1.106 × 10−8
GO:0006364 rRNA processing 1.348 × 10−8
GO:1902600 hydrogen ion transmembrane transport 1.963 × 10−8
GO:0006367 transcription initiation from RNA polymerase II promoter 2.211 × 10−8
GO:0051437 positive regulation of ubiquitin‐protein ligase activity involved in mitotic cell cycle 2.365 × 10−8
GO:0051439 regulation of ubiquitin‐protein ligase activity involved in mitotic cell cycle 4.824 × 10−8
GO:0000398 mRNA splicing, via spliceosome 5.565 × 10−8
GO:0051436 negative regulation of ubiquitin‐protein ligase activity involved in mitotic cell cycle 9.745 × 10−8
GO:0038061 NIK/NF‐kappaB signaling 1.169 × 10−7
GO:0031145 anaphase‐promoting complex‐dependent proteasomal ubiquitin‐dependent protein catabolic process 1.282 × 10−7
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 2.331 × 10−7
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 8.067 × 10−7
GO:0033209 tumor necrosis factor‐mediated signaling pathway 9.747 × 10−7
GO:0000387 spliceosomal snRNP assembly 2.742 × 10−6
GO:0034660 ncRNA metabolic process 4.53 × 10−6
GO:0006521 regulation of cellular amino acid metabolic process 5.739 × 10−6
GO:0050434 positive regulation of viral transcription 6.873 × 10−6
GO:0042776 mitochondrial ATP synthesis coupled proton transport 1.66 × 10−5
GO:0044281 small molecule metabolic process 1.913 × 10−5
GO:0006446 regulation of translational initiation 2.391 × 10−5
GO:0000082 G1/S transition of mitotic cell cycle 2.8 × 10−5
GO:0010499 proteasomal ubiquitin‐independent protein catabolic process 3.292 × 10−5
GO:0019068 virion assembly 3.292 × 10−5
GO:0000209 protein polyubiquitination 3.844 × 10−5
GO:0042254 ribosome biogenesis 4.293 × 10−5
GO:0001731 formation of translation preinitiation complex 4.472 × 10−5
GO:0006368 transcription elongation from RNA polymerase II promoter 4.798 × 10−5
GO:0021888 hypothalamus gonadotrophin‐releasing hormone neuron development 4.944 × 10−5
GO:0002223 stimulatory C‐type lectin receptor signaling pathway 5.147 × 10−5
HT‐CLNPs GO terms
GOID GOTerm P‐value
GO:0043066 negative regulation of apoptotic process 9.969 × 10−11
GO:0044267 cellular protein metabolic process 1.093 × 10−9
GO:0000122 negative regulation of transcription from RNA polymerase II promoter 1.504 × 10−9
GO:0006413 translational initiation 2.324 × 10−9
GO:0045944 positive regulation of transcription from RNA polymerase II promoter 2.996E‐09
GO:0006366 transcription from RNA polymerase II promoter 4.917 × 10−9
GO:0010467 gene expression 1.639 × 10−7
GO:0007623 circadian rhythm 3.873 × 10−7
GO:0001501 skeletal system development 4.605 × 10−7
GO:1901653 cellular response to peptide 8.175 × 10−7
GO:0043065 positive regulation of apoptotic process 1.082 × 10−6
GO:0007179 transforming growth factor beta receptor signaling pathway 4.329 × 10−6
GO:0009409 response to cold 6.217 × 10−6
GO:0006986 response to unfolded protein 6.218 × 10−6
GO:0006446 regulation of translational initiation 7.305 × 10−6
GO:0006412 translation 8.13 × 10−6
GO:0016071 mRNA metabolic process 8.787 × 10−6
GO:0009612 response to mechanical stimulus 1.109 × 10−5
GO:0032496 response to lipopolysaccharide 1.285 × 10−5
GO:0008284 positive regulation of cell proliferation 2.057 × 10−5
GO:0035914 skeletal muscle cell differentiation 2.28 × 10−5
GO:0071479 cellular response to ionizing radiation 2.342 × 10−5
GO:0014070 response to organic cyclic compound 2.375 × 10−5
GO:0030968 endoplasmic reticulum unfolded protein response 2.616 × 10−5
GO:0070301 cellular response to hydrogen peroxide 4.16 × 10−5
GO:0006415 translational termination 5.61 × 10−5
GO:0006414 translational elongation 6.171 × 10−5
GO:0006355 regulation of transcription, DNA‐templated 7.051 × 10−5
GO:0006351 transcription, DNA‐templated 7.28 × 10−5
GO:0006457 protein folding 7.913 × 10−5
GO:0051726 regulation of cell cycle 8.277 × 10−5
GO:0042493 response to drug 8.474 × 10−5
GO:0010501 RNA secondary structure unwinding 9.475 × 10−5
GO:0006915 apoptotic process 9.491 × 10−5
GO:0006950 response to stress 9.576 × 10−5
GO:0034097 response to cytokine 0.0001053
GO:0006987 activation of signaling protein activity involved in unfolded protein response 0.0001053
GO:0071499 cellular response to laminar fluid shear stress 0.0001053
GO:0000398 mRNA splicing, via spliceosome 0.0001095
GO:0048705 skeletal system morphogenesis 0.0001226
GO:0071353 cellular response to interleukin‐4 0.0001237
GO:0016070 RNA metabolic process 0.0001291
GO:0043433 negative regulation of sequence‐specific DNA binding transcription factor activity 0.0001513
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP‐independent 0.000158
GO:0045892 negative regulation of transcription, DNA‐templated 0.0001617
GO:0048662 negative regulation of smooth muscle cell proliferation 0.0002132
GO:0008380 RNA splicing 0.0002219
GO:0043434 response to peptide hormone 0.0002296
GO:0021762 substantia nigra development 0.0002719
GO:0034976 response to endoplasmic reticulum stress 0.00029
Adhesion NPs GO terms
GOID GOTerm P‐value
GO:0030198 extracellular matrix organization 1.294 × 10−17
GO:0007155 cell adhesion 2.035 × 10−10
GO:0030199 collagen fibril organization 2.478 × 10−9
GO:0001501 skeletal system development 8.734 × 10−9
GO:0045944 positive regulation of transcription from RNA polymerase II promoter 1.663 × 10−8
GO:0022617 extracellular matrix disassembly 3.188 × 10−7
GO:0000122 negative regulation of transcription from RNA polymerase II promoter 6.322 × 10−7
GO:0030574 collagen catabolic process 1.183 × 10−6
GO:0007050 cell cycle arrest 1.66 × 10−6
GO:0035987 endodermal cell differentiation 7.714 × 10−6
GO:0007179 transforming growth factor beta receptor signaling pathway 8.171 × 10−6
GO:0001525 angiogenesis 1.4 × 10−5
GO:0001568 blood vessel development 1.842 × 10−5
GO:0006865 amino acid transport 2.386 × 10−5
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 3.834 × 10−5
GO:0045444 fat cell differentiation 4.298 × 10−5
GO:0048146 positive regulation of fibroblast proliferation 5.614 × 10−5
GO:0006366 transcription from RNA polymerase II promoter 5.619 × 10−5
GO:0043001 Golgi to plasma membrane protein transport 6.09 × 10−5
GO:0003007 heart morphogenesis 6.397 × 10−5
GO:0014912 negative regulation of smooth muscle cell migration 6.773 × 10−5
GO:0003333 amino acid transmembrane transport 7.054 × 10−5
GO:1902966 positive regulation of protein localization to early endosome 7.632 × 10−5
GO:0001503 ossification 0.000107
GO:0045599 negative regulation of fat cell differentiation 0.0001124
GO:0048705 skeletal system morphogenesis 0.0001124
GO:0032956 regulation of actin cytoskeleton organization 0.00013
GO:0046825 regulation of protein export from nucleus 0.0001504
GO:0061028 establishment of endothelial barrier 0.0001781
GO:0043277 apoptotic cell clearance 0.0001781
GO:0007219 Notch signaling pathway 0.0001879
GO:0010628 positive regulation of gene expression 0.0002892
GO:0050919 negative chemotaxis 0.000301
GO:0048008 platelet‐derived growth factor receptor signaling pathway 0.0003392
GO:0008284 positive regulation of cell proliferation 0.0003679
GO:0048593 camera‐type eye morphogenesis 0.0003809
GO:0060325 face morphogenesis 0.0003956
GO:0035989 tendon development 0.0003967
GO:0071709 membrane assembly 0.0003967
GO:1903225 negative regulation of endodermal cell differentiation 0.0003967
GO:0030335 positive regulation of cell migration 0.0003991
GO:0002053 positive regulation of mesenchymal cell proliferation 0.0004587
GO:0030154 cell differentiation 0.0004762
GO:0060021 palate development 0.0004797
GO:0007229 integrin‐mediated signaling pathway 0.0005359
GO:0045893 positive regulation of transcription, DNA‐templated 0.0005761
GO:0042340 keratan sulfate catabolic process 0.0006041
GO:0051216 cartilage development 0.0006198
Regulatory NPCs GO terms
GOID GOTerm P‐value
GO:0006954 inflammatory response 4.936 × 10−13
GO:0071294 cellular response to zinc ion 3.004 × 10−9
GO:0045926 negative regulation of growth 9.96 × 10−9
GO:0035666 TRIF‐dependent toll‐like receptor signaling pathway 2 × 10−8
GO:0071222 cellular response to lipopolysaccharide 2.027 × 10−8
GO:0002756 MyD88‐independent toll‐like receptor signaling pathway 2.248 × 10−8
GO:0034138 toll‐like receptor 3 signaling pathway 3.161 × 10−8
GO:0034142 toll‐like receptor 4 signaling pathway 1.434 × 10−7
GO:0071276 cellular response to cadmium ion 1.933 × 10−7
GO:0032496 response to lipopolysaccharide 3.658 × 10−7
GO:0002224 toll‐like receptor signaling pathway 4.694 × 10−7
GO:0010628 positive regulation of gene expression 5.726 × 10−7
GO:0034166 toll‐like receptor 10 signaling pathway 1.709 × 10−6
GO:0034146 toll‐like receptor 5 signaling pathway 1.709 × 10−6
GO:0048711 positive regulation of astrocyte differentiation 1.771 × 10−6
GO:0008285 negative regulation of cell proliferation 1.972 × 10−6
GO:0038124 toll‐like receptor TLR6:TLR2 signaling pathway 3.095 × 10−6
GO:0038123 toll‐like receptor TLR1:TLR2 signaling pathway 3.095 × 10−6
GO:0034162 toll‐like receptor 9 signaling pathway 3.398 × 10−6
GO:0034134 toll‐like receptor 2 signaling pathway 3.726 × 10−6
GO:0006915 apoptotic process 3.786 × 10−6
GO:0070374 positive regulation of ERK1 and ERK2 cascade 4.314 × 10−6
GO:0070301 cellular response to hydrogen peroxide 5.255 × 10−6
GO:0002755 MyD88‐dependent toll‐like receptor signaling pathway 6.844 × 10−6
GO:0071356 cellular response to tumor necrosis factor 1.02 × 10−5
GO:0014070 response to organic cyclic compound 1.168 × 10−5
GO:0048661 positive regulation of smooth muscle cell proliferation 1.242 × 10−5
GO:0071347 cellular response to interleukin‐1 1.37 × 10−5
GO:0009612 response to mechanical stimulus 1.508 × 10−5
GO:0045600 positive regulation of fat cell differentiation 2.168 × 10−5
GO:0043066 negative regulation of apoptotic process 2.473 × 10−5
GO:0033138 positive regulation of peptidyl‐serine phosphorylation 3.34 × 10−5
GO:0007249 I‐kappaB kinase/NF‐kappaB signaling 3.948 × 10−5
GO:0006955 immune response 4.057 × 10−5
GO:0045944 positive regulation of transcription from RNA polymerase II promoter 4.431 × 10−5
GO:0070373 negative regulation of ERK1 and ERK2 cascade 4.914 × 10−5
GO:0043123 positive regulation of I‐kappaB kinase/NF‐kappaB signaling 4.956 × 10−5
GO:0060546 negative regulation of necroptotic process 5.314 × 10−5
GO:2000116 regulation of cysteine‐type endopeptidase activity 7.62 × 10−5
GO:0002246 wound healing involved in inflammatory response 7.62 × 10−5
GO:0039535 regulation of RIG‐I signaling pathway 7.62 × 10−5
GO:0036018 cellular response to erythropoietin 7.62 × 10−5
GO:0070427 nucleotide‐binding oligomerization domain containing 1 signaling pathway 7.62 × 10−5
GO:0002237 response to molecule of bacterial origin 0.000103
GO:0051403 stress‐activated MAPK cascade 0.0001277
GO:0045651 positive regulation of macrophage differentiation 0.0001365
GO:0070555 response to interleukin‐1 0.0001673
GO:0010243 response to organonitrogen compound 0.0001673
GO:0032743 positive regulation of interleukin‐2 production 0.0001763
GO:0006953 acute‐phase response 0.0002129