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. 2021 Nov 26;9(3):2102435. doi: 10.1002/advs.202102435

Figure 6.

Figure 6

In vitro bioassays of the potential hits. a) Tethered indirect transrepression activities of the 72 compounds at the concentration of 10 µm (n = 3 per group). b) GR binding activities of the 16 compounds at the concentration of 10 µm (n = 4 per group). c,d) qPCR analysis of the effect of the DEX, HP‐19, and HP‐24 treatment on the mRNA expression levels of COX‐2 and GILZ (data presented as mean ± SEM, n = 6, p‐values are calculated using one‐way ANOVA followed by Dunnett's post hoc test, *p < 0.05). e) The evolution of the RMSD of Ile581‐Lys777, and the distance between H12 (Ala754‐Tyr764) and Leu589 over time in HP19‐LBD. f) The transformation pathway network in HP19‐LBD.