A) Schematic illustration of using UTMD technique in aFGF targeted delivery. aFGF‐NP prevented DM‐induced metabolism abnormalities and cardiomyocyte interstitial fibrosis: quantitative analysis of the blood glucose of rats (left), the body weight of rats (middle), and the heart‐to‐body ratio (HW/BW) of rats (right); representative pictures of myocardial tissue sections stained with Masson trichrome (400 ×). Arrow indicates myocardial fibrosis stained in blue; quantitative analysis of cardiac collagen volume fraction. Reproduced with permission.[
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] Copyright 2016, Elsevier B.V. B) Schematic illustration of ternary nanoparticle assembly. Lira: Liraglutide; TA: tannic acid. Long‐term cardiovascular protective effect of multiadministrated Lira‐loaded NP‐3. HbA1c: glycosylated hemoglobin, TG: triglyceride, DAG: diacylglycerol, MDA: malondialdehyde, and SOD: superoxidase. Reproduced with permission.[
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] Copyright 2019, Elsevier B.V.