Immune response to sequencing-confirmed reinfection. (A) Maximal likelihood phylogenetic tree with 500 global sequences randomly sampled from GISAID, with patient viral lineage B.1.2 and B.1.429 demarcated with red nodes. (B) Heatmap of collected Luminex and functional features across the respective time points in the patient, corresponding to 34, 70, 126, 159, and 208 days after onset of symptoms during primary infection. Of note, reinfection was identified and confirmed with sequencing between time points 2 and 3.