FIG 2.

Screen of C. albicans AAP mutants for resistance to toxic amino acid analogs reveals novel phenotypes. (A) Relative growth of the SC5314 wild type in SD minimal medium supplemented with toxic amino acid analogs compared to growth in SD medium alone. The analogous proteinogenic amino acid is indicated in parentheses. (B) Representative growth curves for SC5314 in SD medium alone and supplemented with 3,4-dehydro-l-proline, l-canavanine, or l-4-thialysine. (C) Growth inhibition of AAP deletion strains and the stp2Δ mutant relative to the wild type on each toxic amino acid analog. Red indicates growth inhibition of the AAP deletion strain equivalent to that of the wild type, while green indicates unaffected growth of the AAP deletion strain equal to the growth in SD medium alone.