Table 3.

Cox regression multivariable analysis for DFS and OS in patients without metastasis

	DFS (3.5 years) (aHR; 95% CI)	p value	OS (4 years) (aHR; 95% CI)	p value
Age in years	1.03 (1.01–1.06)	0.006	1.07 (1.03–1.10)	<0.001
Stage		0.02		0.04
Stage I	0.45 (0.19–1.02)	0.06	0.58 (0.24–1.40)	0.22
Stage II	0.50 (0.28–0.87)	0.015	0.47 (0.25–0.87)	0.02
RAS (mut. vs. wt)	1.77 (0.96–3.27)	0.07	1.91 (0.96–3.77)	0.07
BRAF (mut. vs. wt)	0.73 (0.24–2.22)	0.67	0.45 (0.16–1.32)	0.15
MMR (def. vs. pro.)	1.00 (0.99–1.01)	0.65	1.00 (0.99–1.01)	0.48

Mut., mutated; wt, wild type; def., deficient; pro., proficient.