Table.
Stromal Cell Types and Functions
| Stromal Cell Type | Phenotypic Markers | Origin | Function |
|---|---|---|---|
| Keratocytes | Keratocan, vimentin | Neural crest | Maintain collagen fibrils and matrix, EBM, DBM |
| Corneal fibroblasts | Vimentin | Keratocytes | Early matrix production, growth factor production (HGF, KGF), precursor to myofibroblasts |
| Fibrocytes | CD34, CD45, COL I | Bone marrow derived | Precursor to myofibroblasts |
| Immature myofibroblasts | Vimentin | Corneal fibroblasts, fibrocytes | Precursor to myofibroblasts |
| Mature myofibroblasts | Vimentin, SMA, desmin | Immature myofibroblasts | Fibrosis, ECM production |
*HGF, hepatocyte growth factor; *KGF, keratinocyte growth factor; SMA, α-smooth muscle actin; COL I, collagen type I; EBM, epithelial basement membrane; DBM, Descemet's basement membrane.