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. 2022 Jan 19;63(1):22. doi: 10.1167/iovs.63.1.22

Table.

Stromal Cell Types and Functions

Stromal Cell Type Phenotypic Markers Origin Function
Keratocytes Keratocan, vimentin Neural crest Maintain collagen fibrils and matrix, EBM, DBM
Corneal fibroblasts Vimentin Keratocytes Early matrix production, growth factor production (HGF, KGF), precursor to myofibroblasts
Fibrocytes CD34, CD45, COL I Bone marrow derived Precursor to myofibroblasts
Immature myofibroblasts Vimentin Corneal fibroblasts, fibrocytes Precursor to myofibroblasts
Mature myofibroblasts Vimentin, SMA, desmin Immature myofibroblasts Fibrosis, ECM production

*HGF, hepatocyte growth factor; *KGF, keratinocyte growth factor; SMA, α-smooth muscle actin; COL I, collagen type I; EBM, epithelial basement membrane; DBM, Descemet's basement membrane.