Table 2.
Adjusted Metabolites With Statistically Significant Differences
| Metabolite | Fold Change (ROP/Non-ROP) | Adjusted P | OR (95% CI) | False Discovery Rate | Pathways |
|---|---|---|---|---|---|
| Glutamic acid gamma-methyl ester | 1.2557 | 0.015 | 1.65E+05 (10.24, 2.66E+09) | 0.0751 | FAO and redox homeostasis |
| 10-Undecenoate (11:1n1) | 1.7239 | 0.028 | 5.19E+04 (3.18, 8.49E+08) | 0.2167 | FAO |
| Picolinoylglycine | 1.1951 | 0.011 | 1.50E+03 (5.21, 4.34E+05) | 0.2504 | FAO |
| 5-Hydroxyhexanoate | 1.5985 | 0.020 | 0.0001 (6.86E-08, 0.248) | 0.9163 | FAO |
| Creatinine | 0.9319 | 0.038 | 8.15E-7 (1.45E-12, 0.46) | 0.0198 | Redox homeostasis |
| Ribitol | 0.9005 | 0.016 | 0.018 (0 .001, 0.48) | 0.0198 | Glycolysis |
| Ornithine | 0.9956 | 0.022 | 5.99E+04 (5.06, 7.09E+08) | 0.2330 | Arginine metabolism |
| 1-Carboxyethylisoleucine | 1.0836 | 0.028 | 0.003 (1.58E-05, 0.535) | 0.4163 | Leucine Isoleucine and Valine Metablism |
| Methylsuccinate | 1.0660 | 0.013 | 9.33E+04 (11.474, 7.59E+08) | 0.4083 | Leucine Isoleucine and Valine Metablism |
The odds ratio (OR) value, 95% confidence interval (CI), and adjusted P value were calculated by multivariate logistic regression (considering delivery mode, feeding strategy, and leukocyte count with statistical differences).