Fig. 8.

Porphyrin-mediated PDI—the effect of charge and lipophilicity on their biological activity in vitro: (A) the chemical structures of tetraphenylporphyrin derivatives with various charge; (B) electronic density maps of the photosensitizers from the total self-consistent field density mapped with the electrostatic potential; (C) the effect of the efflux pump inhibition on high-dose porphyrin-mediated PDI with and without verapamil (Ver) addition; (D) the antibacterial effect of PDI confirmed by confocal microscopy images of the non-treated PDI-treated E. coli.¹³⁰