Table 4. Comparison of patient characteristics according to onset age.
| Variables | Missing values | Infancy onset group (n = 136) | Preschool-age onset group (n = 82) | Childhood onset group (n = 40) | P value | |
|---|---|---|---|---|---|---|
| Severe AD | ||||||
| SCORAD > 50 | 1 | 61 (44.9) | 30 (36.6) | 13 (32.5) | 0.054 | |
| EASI ≥ 21.1 | 14 | 39 (28.7) | 23 (28.0) | 9 (22.5) | 0.073 | |
| Allergic symptoms | ||||||
| Food allergy | 17 | 79 (58.1) | 30 (36.6) | 7 (17.5) | < 0.001*** | |
| Asthma | 11 | 47 (34.6) | 15 (18.3) | 2 (5.0) | < 0.001*** | |
| Diagnosis of other allergic diseases | ||||||
| Food allergy | 19 | 65 (47.8) | 23 (28.0) | 7 (17.5) | < 0.001*** | |
| Asthma | 22 | 34 (25.0) | 8 (9.8) | 2 (5.0) | 0.001** | |
| Allergic rhinitis | 7 | 104 (76.5) | 49 (59.8) | 22 (55.0) | 0.002** | |
| Allergic conjunctivitis | 25 | 54 (39.7) | 18 (22.0) | 11 (27.5) | 0.020* | |
| Family history of allergic diseases | ||||||
| Food allergy | 11 | 31 (22.8) | 15 (18.3) | 3 (7.5) | 0.036* | |
| Atopic dermatitis | 12 | 50 (36.8) | 31 (37.8) | 9 (22.5) | 0.191 | |
| Minor criteria | ||||||
| Xerosis | 30 | 98 (72.1) | 52 (63.4) | 27 (67.5) | 0.040* | |
| Immediate skin reaction | 31 | 35 (25.7) | 13 (15.9) | 6 (15.0) | 0.034* | |
| Hand/foot eczema | 31 | 48 (35.3) | 24 (29.3) | 9 (22.5) | 0.046* | |
| Food intolerance | 31 | 34 (25.0) | 16 (19.5) | 2 (5.0) | 0.003** | |
| Nipple eczema | 31 | 11 (8.1) | 4 (4.9) | 3 (7.5) | 0.841 | |
| Periauricular fissure | 30 | 31 (22.8) | 16 (19.5) | 2 (5.0) | 0.010* | |
| Lesion site | ||||||
| Periorbital | 5 | 77 (56.6) | 45 (54.9) | 14 (35.0) | 0.027* | |
| Cheek | 5 | 54 (39.7) | 20 (24.4) | 8 (20.0) | 0.007** | |
| Ear | 5 | 68 (50.0) | 33 (40.2) | 11 (27.5) | 0.037* | |
| Aggravation by changes in temperature and humidity | 7 | 114 (83.8) | 59 (72.0) | 24 (60.0) | 0.001** | |
| Allergen sensitization | ||||||
| Der f | 43 | 99 (72.8) | 55 (67.1) | 24 (60.0) | 0.004** | |
| Birch | 119 | 43 (31.6) | 16 (19.5) | 8 (20.0) | 0.025* | |
| Oak | 161 | 29 (21.3) | 6 (7.3) | 6 (15.0) | 0.049* | |
| Weed mix | 195 | 14 (10.3) | 3 (3.7) | 1 (2.5) | 0.013* | |
| Inhalant allergen | 31 | 112 (82.4) | 64 (78.0) | 28 (70.0) | 0.012* | |
| Food allergen | 111 | 54 (39.7) | 23 (28.0) | 10 (25.0) | 0.073 | |
| CDLQI (0–30) | 28 | 9.60 ± 6.28 | 8.38 ± 5.45 | 6.86 ± 5.42 | 0.038* | |
| Treatment history | ||||||
| Systemic steroids | 11 | 25 (18.4) | 14 (17.1) | 2 (5.0) | 0.075 | |
| Systemic antibiotics | 11 | 30 (22.1) | 15 (18.3) | 3 (7.5) | 0.048* | |
| Systemic immunosuppressants | 11 | 10 (7.4) | 3 (3.7) | 2 (5.0) | 0.387 | |
Values are presented as number (%), except for CDLQI (mean ± SD).
Some frequencies do not add up to the total number of cases because of missing values.
Statistically significant difference (*P < 0.05, **P < 0.01, ***P < 0.001).
AD = atopic dermatitis, SCORAD = SCORing Atopic Dermatitis, EASI = Eczema Area and Severity Index, Der f = Dermatophagoides farinae, CDLQI = Children’s Dermatology Life Quality Index.