Table 2. Clinical outcomes and complications of the enrolled COVID-19-infected patients according to HBV infection with or without antiviral agent treatment.
| Clinical outcomes | Overall patients (n = 19,160) | HBV-infected patients (n = 675) | Non HBV-infected patients (n = 18,845) | P value | Anti-viral agents user (n = 138) | Anti-viral agents non-user (n = 537) | P value | |
|---|---|---|---|---|---|---|---|---|
| Death | 1,615 (8.4) | 91 (13.5) | 1,524 (8.2) | < 0.001 | 21 (15.2) | 70 (13.0) | 0.487 | |
| In-hospital stay length, days | 20.5 ± 12.9 | 19.9 ± 12.7 | 20.5 ± 12.9 | 0.259 | 19.8 ± 13.0 | 19.9 ± 12.7 | 0.914 | |
| ICU admission | 1,483 (7.7) | 85 (12.6) | 1,398 (7.6) | < 0.001 | 14 (10.1) | 71 (13.2) | 0.389 | |
| Complications | ||||||||
| Liver failure | 68 (0.4) | 13 (1.9) | 55 (0.3) | < 0.001 | 6 (4.3) | 7 (1.3) | 0.032 | |
| MV and ECMO | 971 (5.1) | 54 (8.0) | 917 (5.0) | 0.001 | 4 (2.9) | 50 (9.3) | 0.013 | |
| AKI | 635 (3.3) | 34 (5.0) | 601 (3.3) | 0.015 | 3 (2.2) | 31 (5.8) | 0.123 | |
| CRRT | 190 (1.0) | 19 (2.8) | 171 (0.9) | < 0.001 | 3 (2.2) | 16 (3.0) | 0.778 | |
Data are shown as number (%) or mean ± SD. P values were calculated using the student’s t-test or the χ2 or Fischer exact test, as appropriate.
COVID-19 = coronavirus disease 2019, HBV = hepatitis B virus, ICU = intensive care unit, MV = mechanical ventilation, ECMO = extracorporeal membrane oxygenation, AKI = acute kidney injury, CRRT = continuous renal-replacement therapy.