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. 2022 Jan 25;20:50. doi: 10.1186/s12951-022-01264-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — miR497/TP-HENPs boost intracellular ROS and induce M2 to M1 polarization of macrophages. A ROS in SKOV3-CDDP cells. Scale bar: 50 μm. B Quantitative analysis of ROS in SKOV3-CDDP cells by FCM. C Analysis of the expression of HIF-α using WB assay. D GSH quantity in SKOV3-CDDP cells. E, F Cell supernatant levels of TNF-α and TGF-β1 in different treatment groups of RAW264.7 macrophages. G, H FCM analysis of the expression of M1 macrophage markers (F4/80 + CD86 +) and quantitative analysis of the MFI of PE-CD86. I The ratio of M1/M2 subtype macrophages treated with different groups in vitro