Table 4.
Cox proportional hazards model for overall survival
| Alive (n = 84) | Deceased (n = 172) | Univariate | Multivariate1 | ||
|---|---|---|---|---|---|
| N (%) | N (%) |
Hazard Ratio (95% CI) |
Hazard Ratio (95% CI) | P-value | |
| Antibiotic Use | |||||
| ABT- | 70 (83.3) | 140 (81.4) | 1.00 | 1.00 | |
| ABT + | 14 (16.7) | 32 (18.6) | 1.33 (0.91–1.96) | 1.35 (0.91–2.02) | 0.140 |
| PPI Use | |||||
| No | 62 (73.8) | 133 (77.3) | 1.00 | 1.00 | |
| Yes | 22 (26.2) | 39 (22.7) | 0.91 (0.63–1.29) | 0.92 (0.64–1.33) | 0.667 |
| Prior Chemotherapy | |||||
| No | 44 (52.4) | 66 (38.4) | 1.00 | 1.00 | |
| Yes | 40 (47.6) | 106 (61.6) | 1.42 (1.04–1.93) | 1.47 (1.07–2.03) | 0.018* |
| Age (mean [sd]) | |||||
| NA | 65.6 [10.1] | 65.4 [9.2] | 1.00 (0.99–1.02) | 1.00 (0.98–1.02) | 0.933 |
| ECOG Performance Status | |||||
| 0 | 24 (28.6) | 33 (19.3) | 1.00 | 1.00 | |
| 1/2 | 60 (71.4) | 138 (80.7) | 1.75 (1.19–2.57) | 1.75 (1.19–2.57) | 0.005* |
| Targeted Therapy | |||||
| No | 73 (86.9) | 142 (82.6) | 1.00 | 1.00 | |
| Yes | 11 (13.1) | 30 (17.4) | 1.02 (0.69–1.52) | 1.00 (0.66–1.52) | 0.995 |
| Smoking Status | |||||
| Never | 13 (15.5) | 25 (14.5) | 1.00 | 1.00 | |
| Former | 57 (67.9) | 127 (73.8) | 1.30 (0.85–2.00) | 1.36 (0.88–2.10) | 0.168 |
| Current | 14 (16.7) | 20 (11.6) | 1.02 (0.57–1.84) | 1.06 (0.58–1.92) | 0.859 |
*Statistically Significant, when p < 0.05; 1: Adjusted for PPI, Chemotherapy, Age (Continuous), ECOG (0 vs. combined 1/2), Targeted Therapy, and Smoking Status; *Dead considered as event/1. Alive is reference/0. PPI: Proton pump inhibitor