Table 2.
Follow‐up results for clinical, laboratory, and echocardiographic details
| Variables | ARNI group (n = 144) | ACEI/ARB group (n = 130) | P‐value |
|---|---|---|---|
| Systolic blood pressure (mmHg) | 118.6 ± 27.5 | 121.7 ± 23.4 | 0.435 |
| Diastolic blood pressure (mmHg) | 73.0 ± 14.7 | 75.3 ± 12.8 | 0.305 |
| Heart rate (b.p.m.) | 82.6 ± 23.1 | 79.6 ± 23.2 | 0.425 |
| QRS duration (ms) | 116.6 ± 35.1 | 121.2 ± 37.5 | 0.450 |
| QTc interval (ms) | 436.6 ± 141.6 | 472.6 ± 72.5 | 0.029 |
| BSA (kg/m2) | 1.84 ± 0.18 | 1.84 ± 0.19 | 0.745 |
| Laboratory values | |||
| BNP (pg/mL) | 1396 (507, 3723) | 995 (406, 1820) | 0.029 |
| hs‐TnI (μg/L) | 0.06 (0.03, 0.14) | 0.04 (0.02, 0.14) | 0.183 |
| Creatinine (mmol/L) | 102 (87, 137) | 98 (75, 125) | 0.075 |
| Uric acid (mmol/L) | 537.01 ± 165.81 | 543.79 ± 201.06 | 0.790 |
| Serum potassium (mmol/L) | 4.21 ± 0.71 | 4.13 ± 0.70 | 0.360 |
| Echocardiography findings | |||
| LVEF (%) | 36.26 ± 11.72 | 32.48 ± 10.83 | 0.006 |
| LVEDD (mm) | 60.42 ± 9.57 | 60.55 ± 9.69 | 0.911 |
| E/e′ | 14.67 ± 7.20 | 13.95 ± 5.67 | 0.426 |
| Interventricular septal thickness (mm) | 10.00 ± 1.87 | 10.05 ± 1.93 | 0.867 |
| Left ventricular wall thickness (mm) | 9.65 ± 1.39 | 9.48 ± 1.49 | 0.331 |
| LAD (mm) | 44.18 ± 6.30 | 46.37 ± 7.90 | 0.013 |
| LASID (mm) | 44.93 ± 6.28 | 48.03 ± 7.11 | <0.0001 |
| LATD (mm) | 53.10 ± 8.78 | 62.82 ± 9.09 | <0.0001 |
| LAV (mL) | 57.15 ± 22.33 | 77.41 ± 34.25 | <0.0001 |
| LAVI (mL/m2) | 31.32 ± 13.18 | 42.27 ± 18.83 | <0.0001 |
| LASI | 1.19 ± 0.15 | 1.31 ± 0.09 | <0.0001 |
Abbreviations: BNP, B‐type natriuretic peptide; BSA, body surface area; E/e′, mitral Doppler early velocity/mitral annular early velocity; hs‐TnI, high‐sensitivity troponin I; LAD, left atrium diameter; LASI, left atrial sphericity index; LASID, superior and inferior diameter of left atrium; LATD, transverse diameter of left atrium; LAV, left atrial volume; LAVI, left atrial volume index; LVEDD, left ventricular end‐diastolic dimension; LVEF, left ventricular ejection fraction.