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. 2021 Dec 28;9(1):303–317. doi: 10.1002/ehf2.13754

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© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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DM activated the myocardial NLRP3 inflammasome and caspase‐1 in mice after MI. (A & B) The mRNA and protein levels of NLRP3 and cleaved caspase‐1 were assessed by qPCR and western blotting analysis. Graph right shows densitometric quantification. (C) Representative image of immunofluorescence assays of NLRP3 and cleaved caspase‐1 in LV tissue sections from control and DM hearts after MI. DAPI nuclear staining in blue (scale bar = 50 μm). (D) Representative images of TUNEL‐positive cells in the myocardium from DM and the control group. Original magnification ×400 (scale bar = 50 mm). ^# P < 0.05 DM + MI vs. MI; *P < 0.05 MI vs. controls. DM, diabetes mellitus; MI, myocardial infarction.