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. 2021 Dec 2;9(1):428–441. doi: 10.1002/ehf2.13732

Figure 2.

Figure 2

2MT ameliorates oxidative stress in the heart after ischaemia/reperfusion. (A) Representative images of HEL staining of mice hearts 1 h after sham or I/R operation, followed by saline or 2MT injection, and its quantification (n = 5 for each group). The scale bar indicates 50 μm. **P < 0.01; two‐tailed Student t test. (B) Heat map of differential gene expression. (C) Principal component analysis of microarray data (n = 3 for each group). Red nodes indicate 2MT; black nodes indicate control. (D) Enrichment analysis conducted by DAVID. The top 10 GO pathways are ranked by Benjamini‐adjusted P values and scaled according to the function‐log10 (P value). 2MT, 2‐methyl‐2‐thiazoline; HEL, N ε‐(hexanonyl) lysine; I/R, ischaemia–reperfusion; PC1, first principal component; PC2, second principal component.