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. 2022 Jan 25;20:25. doi: 10.1186/s12915-022-01229-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — UMAP gene cluster annotation and visualization based on gene expression clustering. UMAP plot showing clustering of 22,342 genes based on their expression in 350 pig tissue samples. The resulting 84 gene clusters are outlined and are color coded by mixing the colors associated with each organ system in proportion to the mean squared fraction of total expression among tissues for genes in the cluster. Top: Color legend and cluster map showing cluster ID numbers. Bottom: Annotated cluster names. See Additional file 1: Fig. S4, for basic gene UMAP visualizations