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. 2022 Jan 25;14:8. doi: 10.1186/s13073-021-01009-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Profiling of circRNAs in prostate cancer patients. a Genomic origin of circRNAs. b Estimated exonic length of circRNAs. Bin size = 100 bp. c Number of total circular reads (CPM) per gene versus number of distinct circRNAs per gene. d For each circRNA, the number of circular and corresponding linear reads on a logarithmic scale. Above the red line: Linear > circRNA, below the red line: circRNA > linear. e Total number of circular reads across all patient samples vs. the number of samples expressing each distinct circRNA. The red dotted line marks circRNAs detected in more than 80% of all samples. f Boxplot of total expression (CPM) of abundant circRNA across cancer (LPC and MPC) and AN samples in cohort 1. P value represents Wilcoxon rank-sum test. g–h Volcano plot of (g) abundant circRNAs or (h) circ/lin ratio for abundant circRNAs showing log2 fold change between cancer and AN samples in cohort 1 according to the levels of significance. Horizontal dashed line corresponds to q (g) or p (h) = 0.05. X-axis and Y-axis are plotted on a logarithmic scale (log2 and log10, respectively). CPM = counts per million. FC = fold change