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. 2022 Jan 25;22:107. doi: 10.1186/s12885-022-09203-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Correlation of TIMELESS and RORA expression level with TMB and immune checkpoint in NSCLC samples. Correlation analysis of TIMELESS (A) and RORA (B) expression with TMB. The horizontal axis in the figure represents the expression distribution of the gene, and the ordinate is the expression distribution of the TMB score. The density curve (blue) on the right represents the distribution trend of the TMB score, and the upper density curve (brown) represents the distribution trend of the gene. C Heatmap of the correlation of TIMELESS and RORA with immune checkpoint-related genes in LUAD and LUSC samples. Red means positive correlation and blue means negative correlation. D-G The TIDE score of NSCLC patients with different TIMELESS or RORA expression. *P < 0.05, **P < 0.01, ****P < 0.0001